LUO, YONGZHANG,CHANG, GUODONG,YANG, SHULING,GAO, LEI,FU, YAN
申请号:
CA2675231
公开号:
CA2675231C
申请日:
2008.01.10
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The present invention provides an anti-tumor or anti-angiogenesis medicament,the combination or kit containing the medicament, and the method for producingthesame. The anti-tumor or anti-angiogenesis medicament contains a conjugatecomprising a modifying agent and the angiostatin or its fragments, wherein theconjugate exhibits prolonged in vivo half-life as compared to an unmodifiedangiostatin or its fragments. The modifying agent is selected from the groupconsisting of macromolecular polymers, protein molecules or fragments thereof,peptides, small molecules, or chemical substances of any other forms.