An information processing system according to an embodiment of the present technology includes a controller unit. The controller unit calculates, on a basis of a dynamic acceleration component and a static acceleration component of a detection target moving within a space that are extracted from an acceleration in each direction of three axes of the detection target, a temporal change of the dynamic acceleration component with respect to the static acceleration component, and determines a motion of the detection target on a basis of the temporal change of the dynamic acceleration component.