MCGREGOR, IAIN STEWART,CARSON, DEAN SAMUEL,GUASTELLA, ADAM JOHN,BOWEN, MICHAEL THOMAS
申请号：
ES10819736
公开号：
ES2509270T3
申请日:
2010.09.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A composition comprising oxytocin or an analogue or a derivative of oxytocin set in the ID. SEC. NO: 1 or an agonist oxytocin receptor for use in a method for treating or preventing alcoholism in a subject by reducing alcohol consumption by the subject to a level that is a moderate drinker behavior or alcohol withdrawal, or to inhibit or prevent alcohol consumption by a subject, wherein: (a) said derivative of oxytocin is selected from the group consisting of: a peptide comprising between 6 and 9 residues contiguous amino acid ID. SEC. No. 1 a fusion protein comprising the ID. SEC. No. 1 and a peptide comprising the ID. SEC. NO: 1 and one or more chemical moieties other than amino acid (B) said analog of oxytocin is selected from the group consisting of: 4-serine, isoleucine-8-oxytocin 3- phenylalanine-oxytocin (synonymously oxipresina) 4-threonine-1-hydroxy-desaminooxitocina 4-serine, 8-isoleucinaoxitocina 9-desamidooxitocina 7-D-proline-oxytocin (2,4-diisoleucina) -oxytocin carbetocin (syn, 1- 15 desamino-1-monocarba- [2-O-methyltyrosine] -oxytocin) 7-glycine-oxytocin 4-threonine, glycine-7-oxytocin (syn, TG-OT) desamino-6-carbaoxitocina (syn, DC60) and desamino-di-carba-oxytocin (syn, 1-deamino-1,6- dicarba- [2-Ometiltirosina] -oxytocin) and (c) said receptor agonist oxytocin is selected from the group consisting of: 2-D-tyrosine-oxytocin 5-D-asparagine-oxytocin and 1-hemi-D-cysteine-oxytocin.Una composición que comprende oxitocina o un análogo o un derivado de la oxitocina establecido en la ID. SEC. Nº: 1 o un agonista del receptor de la oxitocina para su uso en un procedimiento para el tratamiento o la prevención del alcoholismo en un sujeto mediante la reducción del consumo de alcohol por parte del sujeto hasta un nivel que constituye un comportamiento bebedor moderado o una abstinencia del alcohol, o para inhibir o prevenir el consumo de alcohol por parte de un sujeto, en la que: (a) dicho derivado de la oxitocina se elige de entre el grupo que consiste en: u
