PROBLEM TO BE SOLVED: To provide a single-stranded nucleic acid molecule using a non-nucleotide structure that can inhibit the expression of a target gene.SOLUTION: The present invention provides an artificial match-type miRNA that is a single-stranded nucleic acid having an X region and a Y region, wherein a 3 end of the X region and a 5 end of the Y region are joined through a terephthalic acid derivative (TP), the X region comprises the guide strand sequence of an hsa-miR-34a mature miRNA, and the Y region comprises a sequence that is perfectly complementary to the X region.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2017,JPO&INPIT【課題】標的遺伝子の発現を抑制できる非ヌクレオチド構造を利用した一本鎖核酸分子の提供。【解決手段】X領域とY領域とを有する一本鎖核酸であり、前記X領域の3’末端と前記Y領域の5’末端とが、テレフタル酸誘導体(TP)を介して連結し、前記X領域は、hsa-miR-34aの成熟miRNAのガイド鎖配列を含み、前記Y領域は、前記X領域と完全に相補な配列を含むことを特徴とする、人工マッチ型miRNAの提供。【選択図】図1
