ANDREW J. TEBBEN,GREGORY D. BROWN,HAI-YUN XIAO,JINGWU DUAN,SHUQUN LIN,STEPHEN T. WROBLESKI,T.G. MURALI DHAR,ZHONGHUI LU
申请号：
BR112017019731
公开号：
BR112017019731A2
申请日:
2016.03.17
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The compounds of formula (I) or a salt of the same are described, (I) in which X is n, W is: (cr3r3) 25, (cr3r3) XY (cr3r3) y, y (cr3r3) 23y, cr3r3y (cr3r3) 2Y, y (cr3r3) 2ycr3r3 and y, R1 R2.R3, R5, R6, R8, x, and y are as defined here. Also described are methods of use of these compounds as modulators of TNFa, and pharmaceutical compositions comprising such compounds.These compounds are useful in the treatment of inflammatory and autoimmune diseases.os compostos de fórmula (i) ou um sal do mesmo são descritos, (i) em que: x é n w é: ¿(cr3r3)2¿5¿, ¿(cr3r3)x¿y¿(cr3r3)y¿, ¿y¿(cr3r3)2¿3¿y¿, ¿cr3r3¿y¿(cr3r3)2¿y¿, ¿y¿(cr3r3)2¿y¿cr3r3¿ e y, r1, r2, r3, r5, r6, r8, x, e y são definidos aqui. são também descritos métodos de uso de tais compostos como moduladores de tnfa, e composições farmacêuticas compreendendo tais compostos. estes compostos são úteis no tratamento de doenças inflamatórias e autoimunes.
