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NOVEL ALPHA-PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME
专利权人:
Toru Miura;Kazuhiro Onogi;Ryohei Sekimoto;Hitomi Aoki;Tadaaki Ohgiya;Rie Ishida;Junya Tagashira;Gen Watanabe
发明人:
Toru Miura,Kazuhiro Onogi,Junya Tagashira,Gen Watanabe,Ryohei Sekimoto,Rie Ishida,Hitomi Aoki,Tadaaki Ohgiya
申请号:
US13318750
公开号:
US20120046308A1
申请日:
2010.05.28
申请国别(地区):
US
年份:
2012
代理人:
摘要:
An α-phenoxybenzeneacetic acid derivative represented by general formula (I), which has both an angiotensin II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, metabolic syndrome or the like, a salt of the derivative, or a solvate of the derivative or the salt; and a pharmaceutical composition containing the derivative, the salt or the solvate. [In the formula, Q represents a group represented by formula (II) or (III) [wherein R1 and R1′ independently represent a C1-6 alkyl group; R2 and R2′ independently represent a substituted or unsubstituted C1-6 alkyl group; R3 represents a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, or a group represented by formula (IV) [wherein X and Y independently represent CH or N; Z represents a C1-6 alkylene chain, or the like; R11 represents a hydrogen atom, a C6-10 aryl group, or the like; and m represents 0 or 1]; and R4 represents a substituted C1-6 alkyl group]; R5 and R6 independently represent a C1-6 alkyl group: R7 represents a carboxyl group, or the like; R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, or the like; and n represents an integer of 1 to 3.]
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