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19-NOR neuroactive steroids and methods of use thereof
专利权人:
SAGE THERAPEUTICS; INC.
发明人:
Gabriel Martinez Botella,Boyd L. Harrison,Albert Jean Robichaud,Francesco G. Salituro,Richard Thomas Beresis
申请号:
US14785192
公开号:
US09365611B2
申请日:
2014.04.17
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, and status epilepticus.
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