A mattress retention system for adjustable beds employs a tension web (16) attached to a top surface (15) of an element (13) of an articulating support structure (12), The tension web (16) is inset from a longitudinal edge and lateral edges of the articulating support structure element (13) and incorporates a first fastener moiety (17) on an extending edge. A mating element (24) is attached to the bottom surface of a mattress (10) adjacent an edge to be restrained. The mating element (24) incorporates a second fastener moiety (29) for operable connection to the first fastener moiety and includes a web section (28 ) having a first edge attached to the bottom surface of t he mattress and a second edge carrying the second fastener moiety (29) for flexibility in attaching the fastener moieties.