The present invention discloses a composition and a medicinal product for reducing body weight and body fat, and a use of said product. The composition contains epigallocatechin gallate, curcumin, and an excipient, wherein the excipient contains at least one of glyceryl dibehenate, polyoxyethylene stearates, polysorbate 80 mixture, vitamin E polyethylene glycol succinate, glyceryl monostearate, and Oleoyl polyoxyl-6 glycerides, or a combination thereof； the polysorbate 80 mixture contains polysorbate 80 and magnesium aluminometasilicate. In animal testing where obesity is induced either prior to or during testing, use of the composition of the present invention leads to a significant reduction of body weight and body fat.本發明公開一種用於減少體重及減少體脂肪的組合物及其醫藥品與應用，該組合物包含表沒食子兒茶素沒食子酸酯、薑黃素、以及一賦形劑，該賦形劑為甘油二山俞酸酯、聚氧乙烯硬脂酸酯、聚山梨醇酯80混合物、維生素E聚乙二醇琥珀酸酯、單硬脂酸甘油酯、以及油酸聚乙二醇-6甘油酯中之至少一者或其組合；而且，該聚山梨醇酯80混合物包含聚山梨醇酯80以及偏矽酸鎂鋁。本發明所述的組合物在先誘導肥胖模式的動物試驗或同時誘導肥胖的動物試驗中，皆具有顯著減少體重與體脂肪的效果。
