PROBLEM TO BE SOLVED: To provide a therapeutic agent for a cerebral nerve disease such as Alzheimer-type dementia.SOLUTION: The present invention provides a therapeutic agent for cerebral nerve disease caused by the degeneration and disorder of nerve cells, the agent comprising (-)-6-(3-[3-cyclopropyl-3-{(1R,2R)-2-hydroxycyclohexyl}ureide]propoxy)-2(1H)-quinoline, represented by the following formula (1), salt thereof or their solvates, as an active ingredient.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】アルツハイマー型認知症等の脳神経疾患治療剤の提供。【解決手段】下記式(1)で表される(-)-6-(3-[3-シクロプロピル-3-{(1R,2R)-2-ヒドロキシシクロヘキシル}ウレイド]プロポキシ)-2(1H)-キノリン、その塩又はそれらの溶媒和物を有効成分とする神経細胞の変性、障害による脳神経疾患の治療剤。【選択図】なし