COMPOSITIONS AND METHODS TO EVALUATE HEPATOBILIARY/GASTROINTESTINAL HEALTH, ENTEROHEPATIC CIRCULATION, AND DRUG INTERACTIONS

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专利权人:

发明人:

JAMES E. POLLI,JEAN-PIERRE RAUFMAN,DIANA VIVIAN

申请号：

US14535397

公开号：

US20150132228A1

申请日:

2014.11.07

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present invention relates to the synthesis and use of a novel trifluorinated bile acid analogue, that being, CA-sar-TFMA which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analogue can be used as a 19F MRI tracer exhibiting an increased half-life due to its resistance to choloylglycine hydrolase.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/