TAKAHASHI, TOMOYA,高桥知也,高橋知也,PAN, I HORNG,潘一红,潘一紅,WEN, SHU FANG,温淑芳,溫淑芳,LU, I HUANG,吕亦晃,呂亦晃,CHUANG, KAI AN,庄凯安,莊凱安
申请号：
TW105118524
公开号：
TWI610676B
申请日:
2016.06.14
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
A nerve cell death inhibitor, an anti-Alzheimers disease agent, a brain hypofunction inhibitor and a drug or food having an anti-Alzheimers disease effect or a brain hypofunction-inhibiting effect, each containing as an active ingredient "a preset partitioned portion that is a portion partitioned in methylene dichloride when an ethanol extract of Rhinacanthus nasuta (L.) Kurz is liquid-liquid partitioned with hexane and methanol and then the portion partitioned in methanol is liquid-liquid partitioned with methylene dichloride and water", "a preset fraction that is a fraction eluted from a silica gel column with an elution solvent, said elution solvent consisting of n-hexane, ethyl acetate and anhydrous methanol, when the preset partitioned portion is subjected to silica gel column chromatography using the elution solvent" or Rhinacanthin C. According to the present invention, a nerve cell death inhibitor having an excellent effect of inhibiting nerve cell death, an anti-Alzheimers disease agent, a brain hypofunction inhibitor and a drug or food having an anti-Alzheimers disease effect or a brain hypofunction-inhibiting effect can be provided.一種神經細胞死抑制劑、抗阿茲海默症劑、抗腦機能減退劑及具有抗阿茲海默症作用或抗腦機能減退作用的醫藥品,含有以[以己烷及甲醇對白鶴靈芝的乙醇萃取物進行液-液分配,以二氯甲烷及水對被甲醇分配的分配物進行液-液分配時,被二氯甲烷分配的規定的分配物]、[將規定的分配物附加於使用由正己烷、乙酸乙酯及無水甲醇構成的溶析溶媒之矽膠管柱層析法時,由矽膠管柱藉由溶析溶媒溶析出的分劃物之規定的分劃物]或白鶴靈芝醌C當作有效成分。依照本發明,可提供具有優良的神經細胞死抑制作用的神經細胞死抑制劑、抗阿茲海默症劑、抗腦機能減退劑及具有抗阿茲海默症作用或抗腦機能減退作用的醫藥品。
