LU GENMIN,PHILLIPS DAVID R.,ANDRE PATRICK,SINHA UMA
申请号：
PL08834136
公开号：
PL2193196T3
申请日:
2008.09.26
申请国别(地区):
PL
年份:
2017
代理人:
摘要：
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
