JUNG, SUNG YOUB,郑圣烨,鄭聖燁,KIM, DAE JIN,金大振,PARK, SUNG HEE,朴晟喜,WOO, YOUNG EUN,禹姈银,禹姈銀,CHOI, IN YOUNG,崔仁荣,崔仁榮,KWON, SE CHANG,权世昌,權世昌
申请号：
TW103138318
公开号：
TWI601744B
申请日:
2012.06.15
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.本發明係關於一種包含調酸素、免疫球蛋白Fc區與非肽基聚合物之複合物，其中該複合物係利用非肽基聚合物共價連接調酸素至免疫球蛋白Fc區所製得，並關於一種包含該複合物而用於預防或治療肥胖之醫藥組成物。本發明該包含調酸素與免疫球蛋白Fc之複合物不同於天然調酸素，可減少食物攝取、抑制胃排空、及促進脂肪分解，而不會有副作用，且亦比天然調酸素展現更優異之受體活化效用與長期持續效力。因此其具有廣泛用於治療肥胖之安全性與效力。
