The present invention provides a kind of medical device control handle or conduits comprising yoke assembly and at least one of following: for activating disk actuator, lever actuater and the ring actuator of additional drag wire in multiple structures manipulation independent of each other of the medical device or conduit. The disk actuator and the yoke assembly have common axis of rotation line, this is because the disk actuator is installed in a part of pulley arm but can rotate independently of the pulley arm. The lever actuater has the rotation axis separated from the rotation axis of the pulley arm and can be located at the distal side of the pulley arm, and wherein its rotation axis is oriented generally perpendicular to the rotation axis of the pulley arm. The ring is installed in the outside of the control handle and can activate another drag wire relative to the control rotatable handle, with another structure for manipulating the conduit. It includes these actuators that each in the disk actuator, lever actuater and ring actuator, which is designed that existing control handle and catheter to be retro fitted into,.