Scott G. Kitchen,Jerome A. Zack,Otto O. Yang,Michael S. Bennett,Balamurugan Arumugam
申请号：
US13045073
公开号：
US09228007B1
申请日:
2011.03.10
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed herein are recombinant human progenitor cells, engineered human thymocytes, and engineered human T cells. The recombinant human progenitor cells are made by transducing a human hematopoietic stem cell with a vector having a nucleic acid molecule which encodes a human T cell receptor specific to a virus, such as Human Immunodeficiency Virus, or an epitope thereof. The recombinant human progenitor cells differentiate and mature into the engineered human thymocytes and the engineered human T cells. Also disclosed herein are methods of inhibiting, reducing or treating a viral infection in a subject, such as a human subject, which comprises administering recombinant human progenitor cells, engineered human thymocytes, and/or engineered human T cells to the subject.
