KIM, MYUNG-HWA,CHUN, KWANG-WOO,YE, IN-HAE,CHOI, JONG-HEE
申请号：
EP11798395
公开号：
EP2586430A4
申请日:
2011.06.23
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention relates to a pharmaceutical composition comprising a phospholipid, cholesterol, an ionic lipid, and nanoparticles comprising a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. According to the present invention, it is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient.
