Michael R. Michaelides,Michael L. Curtin,Huan-Qiu Li,Marina A Pliushchev,Ying Wang,Hongyu H. Zhao,Richard F. Clark,Alan S. Florjancic,Zhiqin Ji,Mariazel Torrent,Ramzi F. Sweis,Anil Vasudevan,Justin D.
申请号:
US15588398
公开号:
US09957274B2
申请日:
2017.05.05
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Compounds having a structure of Formula (I):or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, n, and m are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various EED-related conditions or diseases, including cancer, by administration of such compounds are also provided.