Described herein are neuroactive steroids of the Formula (II):or a pharmaceutically acceptable salt thereof; wherein A, R<;sup>;1<;/sup>;, R<;sup>;2a<;/sup>;, R<;sup>;2b<;/sup>;, R<;sup>;3a<;/sup>;, R<;sup>;3b<;/sup>;, R<;sup>;4a<;/sup>;, R<;sup>;4b<;/sup>;, R<;sup>;5<;/sup>;, R<;sup>;6<;/sup>;and------are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.