The external use medicine composition of satisfactory nuclear acid content of skin permeability is offered.Nuclear acid is made to melt in the low-grade fatty acid ionic liquid of the triethanol amine salt and the diethanolamine salt, solubility of nuclear acid adjusts the organic solvent and/or including the fatty acid ionic liquid of the toriisopuropanoruamin salt and the jiisopuropanoruamin salt, the mixed ionic liquid solution of nuclear acid is produced. The said ionic liquid solution was mixed into the ointment base and the matrix sticking base and the nonaqueous type external use medicine composition was produced by making disperse. The external use medicine composition which contains the nuclear acid which is obtained with this invention is the external use medicine composition which is superior in skin permeability, it is possible to offer the appropriate external use medicine composition according to the type of nuclear acid.皮膚透過性の良好な核酸含有の外用剤組成物を提供する。核酸をトリエタノールアミン塩、ジエタノールアミン塩の低級脂肪酸系イオン液体に溶解させ、有機溶媒及び/又はトリイソプロパノールアミン塩、ジイソプロパノールアミン塩の脂肪酸系イオン液体を加えて、核酸の溶解度を調節し、核酸の混合イオン液体溶液を作製する。該イオン液体溶液を軟膏基剤やマトリックス貼付基剤に混合し分散させることにより、非水系外用剤組成物を作製した。本発明で得られる核酸を含有する外用剤組成物は、皮膚透過性に優れた外用剤組成物であり、核酸の種類に応じて適切な外用剤組成物を提供することができる。
