A kind of construction method of pulmonary fibrosis animal model, the mode construction pulmonary fibrosis animal model being administered in combination using the chemistry or biological agent and chemotactic factor (CF) that cause energy pulmonary fibrosis. Pulmonary fibrosis animal model constructed by the method for the present invention has apparent fibrosis lesion, it is similar to clinical truth height to mankind's study of pulmonary fibrosis characteristic, modeling effect is obvious； lesion is evenly distributed； result is stablized； the death rate is low, can carry out clinical simulation to the pulmonary fibrosis disease of the different courses of disease. Teiology, pathology and the pharmaceutical research of the construction method application what pulmonary fibrosis disease of pulmonary fibrosis animal model of the present invention.
