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METHODE DE TRAITEMENT ET SES FORMES POSOLOGIQUES
专利权人:
PURDUE PHARMA L.P.
发明人:
CIPRIANO, ALESSANDRA,COLUCCI, SALVATORE,HARRIS, STEPHEN,HUMMEL, MICHELLE,KYLE, DONALD,WHITESIDE, GARTH
申请号:
CA3068036
公开号:
CA3068036A1
申请日:
2018.06.29
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
The invention provides an oral dosage form comprising (i) an amount of oxycodone and (ii) an amount of buprenorphine, wherein the weight ratio of the amount of buprenorphine to the amount of oxycodone is greater than 1:40 calculated with the amount of buprenorphine in the dosage form expressed as the equimolar amount of buprenorphine base (Mw = 467.64 g/mol) in mg, and the amount of oxycodone in the dosage form expressed as the equimolar amount of oxycodone hydrochloride (Mw = 351.82 g/mol) in mg. The invention also provides combinations of an opioid agonist and buprenorphine for use to treat pain, wherein the combination achieves a reduction of adverse pharmacodynamic responses (such as, respiratory depression), compared with a corresponding stand-alone opioid therapy. The invention also includes methods of treatment and dosage forms thereof comprising such combinations.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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