SLEEMAN, MARK, W.,GUSAROVA, VIKTORIA,MURPHY, ANDREW J.
申请号：
MYPI 2013004223
公开号：
MY160516A
申请日:
2012.06.14
申请国别(地区):
MY
年份:
2017
代理人:
摘要：
A FULLY HUMAN ANTIBODY OR ANTIGEN-BINDING FRAGMENT OF A HUMAN ANTIBODY THAT SPECIFICALLY BINDS AND INHIBITS OR INTERFERES WITH AT LEAST ONE ACTIVITY OF HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 (hANGPTL3) IS PROVIDED. THE HUMAN ANTI-hANGPTL3 ANTIBODIES ARE USEFUL IN TREATING DISEASES OR DISORDERS ASSOCIATED WITH ANGPTL3, SUCH AS HYPERLIPIDEMIA, HYPERLIPOPROTEINEMIA AND DYSLIPIDEMIA, INCLUDING HYPERTRIGLYCERIDEMIA, HYPERCHOLESTEROLEMIA, CHYLOMICRONEMIA, AND SO FORTH. FURTHERMORE, THE ANTI-hANGPTL3 ANTIBODIES CAN BE ADMINISTERED TO A SUBJECT IN NEED THEREOF TO PREVENT OR TREAT DISEASES OR DISORDERS, FOR WHICH ABNORMAL LIPID METABOLISM IS A RISK FACTOR. SUCH DISEASES OR DISORDERS INCLUDE CARDIOVASCULAR DISEASES, SUCH AS ATHEROSCLEROSIS AND CORONARY ARTERY DISEASES； ACUTE PANCREATITIS； NONALCOHOLIC STEATOHEPATITIS (NASH)； DIABETES； OBESITY； AND THE LIKE.
