596903 Disclosed is the (S)-enantiomer of 1&rsquo-{ [5-(trifluoromethyl)furan-2-yl]methyl} spiro[furo[2,3-f][1,3]benzodioxole-7,3&rsquo-indol]-2&rsquo(1&rsquoH)-one having the following formula (I-S) or a pharmaceutically acceptable solvate, which is useful for treatment of disease or condition ameliorated or alleviated by the inhibition of a voltage-gated sodium channel in mammal such as pruritis, neuropathic pain, inflammatory pain, visceral pain, cancer pain, dental pain, chemotherapy pain, trauma pain, surgical pain, labour pain, neurogenic bladder, ulcerative colitis, chronic pain, persistent pain, peripherally mediated pain, centrally mediated pain, chronic headache, migraine headache, sinus headache, tension headache, phantom limb pain, or peripheral nerve injury.
