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NANOPARTICLE-BASED GENE DELIVERY SYSTEMS
专利权人:
CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMY COOPERATION
发明人:
HAN, MIN SU,LEE, KANGSEOK,KIM, DONG-EUN
申请号:
EP10723475
公开号:
EP2496268A4
申请日:
2010.03.18
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention provides a gene delivery system containing nanoparticles. In more detail, the present invention provides a gene delivery system containing (a) a nanomaterial (b) an oligonucleotide as an universal binding partner covalently linked to the surface of the nanomaterial and (c) a cargo comprising (i) a complementary oligonucleotide containing a nucleotide sequence complementary to the universal binding partner as a binding counter-partner, and (ii) an inhibitory molecule having a nucleotide sequence complementary to a target gene of interest to be inhibited or an inducible molecule having a nucleotide sequence of a target gene of interest to be expressed. The present invention is a gene delivery system capable of feasibly deliver aptamer, siRNA, shRNA, miRNA, ribozyme, DNAzyme, PNA or gene as well as antisense oligonucleotide into the cells. In addition, the present invention is more efficient than the commercially available gene transfer reagent in respect to the degree of knockdown of target protein expression.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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