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DEVELOPMENTAL DISORDER INHIBITING MATERIAL
专利权人:
三洋化成工業株式会社;国立大学法人京都大学;KYOTO UNIV;SANYO CHEM IND LTD
发明人:
SUZUKI SHIGEHIKO,鈴木 茂彦,KAWAI KATSUYA,河合 勝也,KAWABATA SHINGO,川端 慎吾
申请号:
JP2016098931
公开号:
JP2016216453A
申请日:
2016.05.17
申请国别(地区):
JP
年份:
2016
代理人:
摘要:
PROBLEM TO BE SOLVED: To provide developmental disorder inhibiting material for use in inhibiting the development of complications, such as developmental disorder associated with wound contraction in the recovery process of a mucosal defective injury.SOLUTION: The present invention relates to a developmental disorder inhibiting material containing protein (A) having a GAGAGS sequence (1) as well as the following amino acid sequence (X) and/or the following amino acid sequence (X'), wherein the total ratio of the β turn structure and the random coil structure of the above-mentioned protein (A) determined by circular dichroism spectrum method is 60-85%, the total ratio of the number of the amino acids of the above-mentioned amino acid sequence (X) and the number of the amino acids of the above-mentioned amino acid sequence (X') in the number of the whole amino acids of the above-mentioned protein (A) is 50-70%, the above-mentioned developmental disorder inhibiting material is in cotton-like form, the bulk density of the above-mentioned developmental disorder inhibiting material is 0.1-100 mg/ml, the water content in the above-mentioned developmental disorder inhibiting material exceeds 0% by weight to 20% by weight or less. Amino acid sequence (X): at least one amino acid sequence selected from a VPGVG sequence (2), a GVGVP sequence (3), and a GAHGPAGPK sequence (4). Amino acid sequence (X'): an amino acid sequence in which one or two amino acids in amino acid sequence (X) are respectively substituted by lysine or arginine.SELECTED DRAWING: None【課題】粘膜欠損創の治癒過程にみられる創収縮に伴う発育障害等の合併症の発現を抑制するために用いる発育障害抑制材を提供する。【解決手段】GAGAGS配列(1)並びに下記アミノ酸配列(X)及び/又は下記アミノ酸配列(X’)を有するタンパク質(A)を含む発育障害抑制材であって、円二色性スペクトル法により求めた上記タンパク質(A)のβターン構造とランダムコイル構造との合計の割合が60~85%であり、上記タンパク質(A)の全アミノ酸の個数のうち上記アミノ酸配列(X)のアミノ酸の個数及び上記アミノ酸配列(X’)のアミノ酸の個数の占める合計の割合が50~70%であり、上記発育障害抑制材が綿状であり、上記発育障害抑制材のかさ密度が0.1~100mg/mlであり、上記発育障害抑制材中の水分含有率が0重量%を超え、20重量%以下である発育障害抑制材。アミノ酸配列(X):VPGVG配列(2)、GVGVP配列(3)及びGAHGPAGPK配列(4)からなる群より選ばれる少なく
来源网站:
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