ARMANDO URBINA,BENJAMENIN JOSEPH LITTLER,DAVID ANDREW SIESEL,FRANCOISE YVONNE THEODORA MARIE PIERARD,JEAN-DAMIEN CHARRIER,JOHN STUDLEY,PAUL ANGELL,ROBERT MICHAEL HUGHES,STEVEN JOHN DURRANT,YI SHI
申请号：
BR112014007721
公开号：
BR112014007721A2
申请日:
2012.09.28
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract [00282] the present invention relates to processes and intermediates for preparing compounds useful as inhibitors of atr kinase, such as aminopyrazine-isoxazole derivatives and related molecules. the present invention also relates to compounds useful as inhibitors of atr protein kinase. the invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention； methods of treating of various diseases, disorders, and conditions using the compounds of this invention； processes for preparing the compounds of this invention； intermediates for the preparation of the compounds of this invention； and solid forms of the compounds of this invention. [00283] the compounds of this invention have formula i or ii: wherein the variables are as defined herein. -------------------------------------------------- ------------------------ Translation of the abstract patent summary "processes for preparing compounds useful as atrinase inhibitors". The present invention relates to processes and intermediates for preparing compounds useful as atrinase inhibitors, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as protein kinase inhibitors. This invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention； methods for treating various diseases, disorders and conditions with the use of compounds of this invention； processes for preparing the compounds of this invention； intermediates for the preparation of the compounds of this invention； and solid forms of the compounds of this invention. The compounds of this invention have formula I or II wherein the variables are as defined herein.abstract [00282] the present invention relates to processes and intermediates for preparing compounds useful as inhibitors of atr kinase, such as aminopyrazine-isoxazole derivatives and related molecules. the present invention also relates to compound
