ROBL, JEFFREY A.,SULSKY, RICHARD B.,AUGERI, DAVID J.,MAGNIN, DAVID R.,HAMANN, LAWRENCE G.,BETEBENNER, DAVID A.
申请号：
ES05005368
公开号：
ES2456667T3
申请日:
2001.03.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound that has the structure. where x is 0 or 1 and y is 0 or 1, with the proviso that x>； = 1 when y>； = 0 and x>； = 0 when y>； = 1； and in which n is 0 or 1； X is H； R1 R2, R3 and R4 are the same or different and are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, bicycloalkyl, tricycloalkyl, alkylcycloalkyl, hydroxyalkyl, hydroxyalkylcycloalkyl, hydroxycycloalkyl, hydroxyalkylcycloalkyl, cycloalkylcycloalkyl, alkylcycloalkyl, alkylcycloalkyl, alkyl , aryl, aralkyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl or cycloheteroalkylalkyl； all optionally substituted through available carbon atoms with 1, 2, 3, 4 or 5 groups selected from hydrogen, halo, alkyl, polyhaloalkyl, alkoxy, haloalkoxy, polyhaloalkoxy, alkoxycarbonyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, polycycloalkyl, heteroarylamino , arylamino, cycloheteroalkyl, cycloheteroalkylalkyl, hydroxy, hydroxyalkyl, nitro, cyano, amino, substituted amino, alkylamino, dialkylamino, thiol, alkylthio, alkylcarbonyl, acyl, alkoxycarbonyl, aminocarbonyl, alkynylaminocarbonyl, alkylaminocarbonyl, alkenylaminocarbonyl, alkylcarbonyloxy, alkylcarbonylamino, arylcarbonylamino, alkylsulfonylamino, alkylaminocarbonylamino, alkoxycarbonylamino, alkylsulfonyl, aminosulfinyl, aminosulfonyl, alkylsulfinyl, sulfonamido or sulfonyl； and R1 and R3 can optionally be taken together to form - (CR5R6) m- in which m is from 2 to 6, and R5 and R6 are the same or different and are independently selected from hydroxy, alkoxy, H, alkyl, alkenyl, alkynyl , cycloalkyl, halo, amino, substituted amino, cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloheteroalkylalkyl, alkyloxylamino, arylcarbonylamino, alkoxycarbonylamino, aryloxycarbonylamino alkoxycarbonyl, or may together take R4 or arylamino, or together, may take R4 together (CR7R8) p- in which p is from 2 to 6, and R7 and R8 are the same or different and are independently
