COMPOSITIONS POUR INDUIRE UNE DIFFÉRENCIATION EN CELLULES RÉTINIENNES À PARTIR DE CELLULES PROGÉNITRICES RÉTINIENNES OU POUR INDUIRE UNE PROLIFÉRATION DE CELLULES RÉTINIENNES COMPRENANT DES ACTIVATEURS DE LA VOIE DE SIGNALISATION WNT
Disclosed is a composition for inducing the proliferation of retinal cells or the differentiation of retinal progenitor cells into retinal cells. The composition, similar to in vivo conditions for development during embryogenesis, induces stem cells to differentiate into a multitude of photoreceptor cells at high yield within a short period of time, without an additional gene transfer. In addition, the differentiated photoreceptor cells are useful in cellular therapy because they, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.
