XU, JIANJUN,KROPF, JEFFREY E.,GEGE, CHRISTIAN,FARAND, JULIE,CURRIE, KEVIN S.,BLOMGREN, PETER A.
申请号：
ARP170101594
公开号：
AR108710A1
申请日:
2017.06.09
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Claim 1: a compound calculated according to formula (1),Q is phenyl or pyridine, each of which is replaced by one or two alternatives selected from halogen, methyl, ch8322； (f) - chf832222；and -CF₃；Z is a compound of formula (2) or (3)；L selected from the contact group, tar-c833218331；e. Asphalt-c83217c8333323-o -；X is ch, c-ch832323,O n； R is asphalt-c832131；where: said C₁₋₄-alkyl is optionally substituted with 1 to 3 substituents independently selected from fluoro, hydroxyl, C₁₋₃-alkoxy,e. Fluorescence-alcoxi-c833213, 123；and said C₃₋₆-cycloalkyl is optionally substituted with 1 to 3 substituents independently selected from fluoro, hydroxyl, C--alkyl,Fluorination asphalt c8321c83318323；C₁₋₃-alkoxy,e. Fluorination-alcoxi-c8332123；R2 is hydrogen, fluorination, ch8323,-CH₂F, -CHF₂,O CF83223；R3: halogen, tar-c832131；Halo asphalt-c8321c83318324；C₁₋₄-alkoxy,or halo-alkoxy-C₁₋₄；R830808 is hydroxy, alcoxi-c83217c83318326a,halo-alkoxy-C₁₋₆,or -NR⁵R⁶；R830909 is hydrogen, hydrocarbon-c83218331-832626；or halo-alkyl-C₁₋₆；R⁶ is hydrogen or C--alkyl,wherein said C₁₋₆-alkyl is optionally substituted with 1 to 6 substituents independently selected from halogen, -SO₃H, and -CO₂H； and n is 0 or 1； or a pharmaceutically acceptable salt, a stereoisomer, a mixture of stereoisomers, or a tautomer thereof.Reivindicación 1: Un compuesto de acuerdo con la fórmula (1), donde Q es fenileno o piridileno, cada uno de los cuales está opcionalmente sustituido con uno o dos sustituyentes seleccionados entre halógeno, metilo, -CH₂F, -CHF₂, y -CF₃； Z es un compuesto de fórmula (2) ó (3)； L se selecciona del grupo que consiste en un enlace, alquileno-C₁₋₃, y alquileno-C₁₋₃-O-； X es CH, C-CH₃, o N； R¹ es alquilo-C₁₋₄ o cicloalquilo-C₃₋₆, donde: dicho alquilo-C₁₋₄ está opcionalmente sustituido con 1 a 3 sustituyentes seleccionados independientemente entre fluoro, hidroxilo, alcoxi-C₁₋₃, y fluoro-alcoxi-C₁₋₃, y dicho cicloalquilo-C₃₋₆ está opcionalmente sustituido con 1 a 3 sustituyentes seleccionados
