Rajan George,Lorne Tyrrell,Antoine Noujaim,Dakun Wang,Allan Ma
申请号:
US13209979
公开号:
US20120070435A1
申请日:
2011.08.15
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Disclosed herein are compositions and methods for eliciting immune responses against antigens. In particular embodiments, the compounds and methods elicit immune responses against antigens that are otherwise recognized by the host as “self” antigens. The immune response is enhanced by presenting the host immune system with a chimeric antigen comprising an immune response domain and a target binding domain, wherein the target binding domain comprises a xenotypic antibody fragment. By virtue of the target binding domain, antigen presenting cells take up, process, and present the chimeric antigen, eliciting both a humoral and cellular immune response.