Compounds having S1P receptors (especially edg-6, preferably edg-1 and edg-6) binding abilities, such as the compounds of the present invention represented by formula (I), their salts, their solvates, or their prodrugs, S1P receptors Edg-6, preferably edg-1 and edg-6) have the ability to combine, and are useful for rejection against graft, graft versus host disease, autoimmune disease, and prevention of allergic disease and \/ or treatment. Ring a is an annular group an annular group ring B may have a substituent the X is a spacer of 1 to 8 atoms of the main chain for example, the Y is a spacer of 1 to 10 atoms of the main chain for example, where n is 0, 1 n is 0, M is 1 and R1 is hydrogen atom, substituent If n is 1, M may be 0, 1 to 7 integers, and R1 may be the same or different when R is greater than 2).S1P受容体(特にEDG-6、好ましくはEDG-1およびEDG-6)結合能を有する化合物、例えば一般式(I)で示される本発明化合物、その塩、その溶媒和物、またはそれらのプロドラッグはS1P受容体(特にEDG-6、好ましくはEDG-1およびEDG-6)結合能を有し、移植に対する拒絶反応、移植片対宿主病、自己免疫性疾患、アレルギー性疾患等の予防および/または治療に有用である。(式中、環Aは環状基;環Bは置換基を有していてもよい環状基;Xは主鎖の原子数1~8のスペーサー等;Yは主鎖の原子数1~10のスペーサー等;nは0、1;nが0の場合、mは1、かつR1は水素原子、置換基;nが1の場合、mは0、1~7の整数、かつR1は置換基、かつmが2以上のときR1は同じでも異なっていてもよい)。
