ADJEI, AKWETE, L.,CHEN, SIBAO,KUPPER, ROBERT, JOE,MANCINELLI, VINCENT
申请号：
SG11201405011P
公开号：
SG11201405011PA
申请日:
2013.03.01
申请国别(地区):
SG
年份:
2014
代理人:
摘要：
Disclosed in certain embodiments is an immediate release solid oral dosage form comprising a plurality of particles, each particle comprising: (i) a core comprising an inert excipient and an active agent, wherein the inert excipient is layered with the active agent； and (ii) a material that is sensitive to acidic pH layered on the core； wherein the plurality of particles are dispersed in a matrix comprising a gelling agent； and wherein the dosage form releases at least about 70% of the active agent within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml 0.1N HCl at 37° C.
