Systems and methods are disclosed for management of anesthetized patients. The systems and methods can enable determination of whether the patient risks an anesthetic complication, an intraoperative stroke, or awareness during anesthesia. The disclosed systems and methods can involve receiving a signal from EEG electrodes on the head of a patient during presentation of a stimuli to the patient. This signal can be used to generate segment posteriorization index values and/or synchronization values. Based on synchronization values anesthesia depth of the patient can be reduced or a surgical intervention performed. Based on segment posteriorization index values anesthesia depth of the patient can be increased.
