CUJEC THOMAS P.,MARIANI ROBERTO,HAYS PUTNAM ANNA-MARIA A.,KEEFE WILLIAM M.,KNUDSEN NICK,HO LILLIAN,PINKSTAFF JASON,KRAYNOV VADIM
申请号：
NZ60270208
公开号：
NZ602702A
申请日:
2008.03.19
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Patent No. 602702 Disclosed is a modified FGF-21 polypeptide that maintains a biological activity of an unmodified human FGF-21 polypeptide, wherein said modified FGF-21 polypeptide comprises an amino acid sequence that: (i) is between 85% identical and 90% identical to a sequence set forth in HPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS and (ii) comprises at least one non-naturally encoded amino acid each of which is at a position corresponding to residue 72, 77, 86, 87, 91, 104, 108, 110, 126, 131, or 146 of HPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS.
