Crosslinkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs

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专利权人:

イムノージェン インコーポレーテッド

发明人:

ウィッジソン，ウェイン，チャールズ,ウィッジソン,ウェイン,チャールズ

申请号：

JP2010237271

公开号：

JP5476272B2

申请日:

2010.10.22

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

Disclosed is a method of making conjugates of cell binding agents and small molecule drugs comprising reacting a cell binding agent with a bifunctional cross-linking moiety to thereby provide the cell binding agent with a reactive disulfide group and then reacting the modified cell binding agent with a small molecule drug comprising a free thiol group. Bifunctional cross-linking moieties are also disclosed.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/