METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE 2 SULFATASE

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专利权人:

发明人:

ZHU GAOZHONG,LOWE KRIS,SHAHROKH ZAHRA,CHRISTIAN JAMES,FAHRNER RICK,PAN JING,WRIGHT TERESA LEAH,CALIAS PERICLES

申请号：

IN759/DELNP/2013

公开号：

IN2013DN00759A

申请日:

2013.01.24

申请国别(地区):

IN

年份:

2014

代理人:

摘要：

The present invention provides among other things compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate 2 sulfatase (I2S) protein salt and a polysorbate surfactant for the treatment of Hunters Syndrome.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/