The present invention relates to a composition comprising:a. bioactive bioceramic hollow beads comprising an opening in the bead wall, said beads having a size in the range of from 80µm to 3000µm, said opening in the bead wall having a diameter of 60µm to 2500µm, said bead wall having a thickness of 20µm to 1000µm and a microporosity of less than 10µm of at least 3%, andb. a compound chosen from proteins and micro- or nanofibers.