Alexander HIRD,Dedong WU,Wenzhan YANG,Matthew, Alan BELMONTE,John, Paul SECRIST,Daniel, William ROBBINS,Steven, Lee KAZMIRSKI,Bo PENG,Jeffrey JOHANNES,Michelle, Laurae LAMB,Qing YE,Xiaolan ZHENG
申请号：
MX2018012711
公开号：
MX2018012711A
申请日:
2017.04.21
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22 -pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octa triaconta- 1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carbo xylic acid (Formula I) and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia- 5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,2 4.030,35]octatriaconta- 1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carbo xylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.Se da a conocer un compuesto que es ácido 17-cloro-5,13,14,22-tetr ametil-28-oxa-2,9-ditia-5,6,12,13,22-pentaazaheptaciclo[27.7.1.14 ,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14, 16,18,20,23,29,31,33,35-tridecaeno-23-carboxílico (fórmula I) (ver Fórmula) y enantiómeros y sales farmacéuticamente aceptables del mismo. También se dan a conocer composiciones farmacéuticas de ácido 17-cloro-5,13,14,22-tetrametil-28-oxa-2,9-ditia-5,6,12,13 ,22-pentaazaheptaciclo[27.7.1.14,7.011,15.016,21.020,24.030,35]oc tatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaen o-23-carboxílico, y enantiómeros y sales farmacéuticamente aceptables del mismo, y métodos de tratamiento del cáncer con tales compuestos y composiciones.
