Mathias OELKE,Kristi JONES,Sojung KIM,Lauren SUAREZ,Ken CARTER,Scott CARMER,Dan BEDNARIK,Vineetha EDAVANA,Emily LU
申请号：
US16707309
公开号：
US20200215115A1
申请日:
2019.12.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides an isolated cell composition, which in some embodiments is suitable for adoptive immunotherapy, as well as methods of manufacturing the cell compositions and methods of treatment with the cell compositions. The composition comprises, in a pharmaceutically acceptable carrier, at least about 106 CD8+ T cells specific for target peptide antigen(s), which comprises T memory stem (TSCM) cells. In various embodiments, the composition is from about 1% to about 100% T memory stem cells, providing for a robust and durable adoptive therapy, as well as providing for T cell engineering advances.
