CORKEY, Britton Kenneth,ELZEIN, Elfatih,JIANG, Robert H.,KALLA, Rao V.,KOBAYASHI, Tetsuya,KOLTUN, Dmitry,LI, Xiaofen,MARTINEZ, Ruben,NOTTE, Gregory,PARKHILL, Eric Q.,PERRY, Thao,ZABLOCKI, Jeff,VENKATA
申请号:
HK16114404.3
公开号:
HK1238627A
申请日:
2016.12.19
申请国别(地区):
HK
年份:
2018
代理人:
摘要:
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R 1 , X 1 , X 2 , Y and R 2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.