萘啶化合物及其用途农业专利-农业专业知识服务系统

发明人:: KELLAR, TERRY,凯乐　泰瑞,凱樂　泰瑞,LIANG, JUN,梁　军,梁　軍,MALHOTRA, SUSHANT,梅尔荷朵拉　苏山特,梅爾荷朵拉　蘇山特,MENDONCA, ROHAN V.,曼多卡　洛罕　Ｖ,SIU, MICHAEL,休　麦克,休　麥克,STIVALA, CRAIG,史迪瓦拉　克雷格,TELLIS, JOHN C.,泰利斯　约翰　Ｃ

摘要：: Naphthyridine compounds of formula (I):,variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.本發明描述式(I)之萘啶化合物：，其變化形式，及其作為HPK1 (造血激酶1)之抑制劑之用途。該等化合物適用於治療HPK1依賴性病症及增強免疫反應。本發明亦描述抑制HPK1之方法、治療HPK1依賴性病症之方法、增強免疫反應之方法及製備萘啶化合物之方法。