A rigidizable endoluminal access device includes a handle assembly 110, a flexible neck, a tip, and at least one lumen extending therethrough. Lumens are in fluid communication with entry ports located at the handle assembly and exit ports positioned on the tip. In one embodiment, entry ports and exit ports are angled with respect to one another. Lumens are configured to receive any suitable surgical instrument. The handle assembly includes an over-center toggle mechanism adapted to stiffen the flexible neck.