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SOLID DOSAGE FORM COMPRISING SOLID DISPERSION AND METHOD FOR PRODUCING THE SAME
专利权人:
发明人:
HOSHINO TAKAFUMI,KUSAKI FUMIE,MARUYAMA NAOSUKE,NISHIYAMA YUICHI,FUKUI IKUO,UMEZAWA HIROSHI
申请号:
IN1736/CHE/2007
公开号:
IN251267B
申请日:
2007.08.07
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
Provided are a solid dosage form comprising a solid dispersion that allows a drug in the preparation to be rapidly-dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising a solid dispersion, the dispersion comprising: a poorly soluble drug, a water-soluble polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μ m and a specific surface area measured by BET method of at least 1.0 m2/g. Moreover, provided is a method for producing a solid dosage form comprising a solid dispersion, the method comprising steps of: spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μ m and a specific surface area measured by BET method of at least 1 - 0 m2/g and serving as a disintegrant and granulating the resultant and drying.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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