The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein n, m, R1, R2, R3, R4, and R5 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (1), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.本申請案提供式(J)化合物，或其醫藥學上可接受之鹽、異構體、互變異構體或混合物，其中n、m、R1、R2、R3、R4及R5如本文中所述。該等化合物為磷脂醯肌醇3-激酶(PI3K)之活性抑制劑且適用於治療由一或多種PI3K同功異型物介導之病狀。本申請案進一步提供包括式(I)化合物或其醫藥學上可接受之鹽、異構體、互變異構體或混合物之醫藥組合物，及使用此等化合物及組合物來治療由一或多種PI3K同功異型物介導之病狀的方法。
