結合至肌肉生長抑制素(MYOSTATIN)以纖維連接蛋白為主之支架結構域蛋白質农业专利-农业专业知识服务系统

发明人:: CLOAD, SHARON T.,克罗　雪伦Ｔ,克羅　雪倫Ｔ,ENGLE, LINDA,恩格　琳达,恩格　琳達,LIPOVSEK, DASA,力珀萨　达沙,力珀薩　達沙,MADIREDDI, MALAVI,玛迪瑞迪　玛拉维,瑪迪瑞迪　瑪拉維,RAKESTRAW, GINGER CHAO,雷司托　金杰　佳欧,雷司托　金傑　佳歐,SWAIN, JOANNA F.,史文　乔安娜Ｆ,史文　喬安娜Ｆ,ZHA,克罗雪伦T,克羅雪倫T,恩格琳达,恩格琳達,力珀萨达沙,力珀薩達沙,玛迪瑞迪玛拉维,瑪迪瑞迪瑪拉維,雷司托金杰佳欧,雷司托金傑佳歐,史文乔安娜F,史文喬安娜F

摘要：: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.本發明係關於結合至肌肉生長抑制素以纖維連接蛋白為主之支架結構域蛋白質。本發明亦關於此等蛋白質在治療性應用中治療肌肉萎縮症、惡病質、少肌症、骨關節炎、骨質疏鬆症、糖尿病、肥胖症、COPD、慢性腎病、心臟衰竭、心肌梗塞及纖維化之用途。本發明進一步關於包含該等蛋白質之細胞、編碼該等蛋白質或其片段之聚核苷酸及包含編碼該等蛋白質之聚核苷酸的載體。