Factor VII or Factor VIIa Gla domain variants

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专利权人:

Kim Vilbour Andersen;Jesper Mortensen Haaning;Claus Bornaes

发明人:

Jesper Mortensen Haaning,Kim Vilbour Andersen,Claus Bornaes

申请号：

US11424035

公开号：

US08987202B2

申请日:

2006.06.14

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Gla domain variants of human Factor VII or human Factor VIIa, comprising 1-15 amino acid modifications relative to the human Factor VII or human Factor VIIa sequence shown in SEQ ID NO:1, wherein a hydrophobic amino acid residue has been introduced by substitution in position 34； or having an amino acid substitution in position 36； and use of the variants for the treatment of intracerebral haemorrhage (ICH) or trauma.

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中国工程科技知识中心

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