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DOSAGE FORM, AND METHODS FOR PREPARING DOSAGE, AND TREATMENT OF A BAD CONDITION IN A PATIENT
专利权人:
PHENOMIX CORPORATION
发明人:
ZHEN-PING WU,RICHARD ALEXANDER MOORE JR.
申请号:
BRPI0811845
公开号:
BRPI0811845A2
申请日:
2008.05.21
申请国别(地区):
BR
年份:
2014
代理人:
摘要:
A dosage form is provided for an anti-diabetic DPP-IV inhibitor of formula (I) as its tartarate salt, wherein the purity of the active pharmaceutical ingredient is maintained over a prolonged storage period under conditions similar to those likely encountered in home storage of the medication by a diabetic patient. A formulation free of calcium salts such as calcium phosphate, but including microcrystalline cellulose, copovidone, crospovidone, colloidal silicon dioxide, and magnesium stearate, when compacted into a tablet with the active pharmaceutical ingredient, was shown to be stable for at least six months at 40° C. and 75% relative humidity. Methods for preparation of the dosage form are also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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