Eddy Jean Edgard Freyne,Kristof Van Emelen,Marc Willems,Peter Jacobus Johannes Antonius Buijnsters,Pierre Henri Storck,Timothy Pietro Suren Perera,Virginie Sophie Poncelet,Werner Constant Johan Embrec
申请号：
BRPI0417534
公开号：
BRPI0417534B1
申请日:
2004.12.15
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
\"Derived from pirido and pirimidopirimidina as antiproliferative agents.The present invention relates to compounds of the formula to the forms of N - oxide, the salts of addition and the forms estereoquimicamente isom\u00e9ricas pharmacologically acceptable to them,In that a\u00ac 1\u00ac - a\u00ac 2\u00ac = a\u00ac 3\u00ac - a\u00ac 4\u00ac represents a radical selected divalente n - CH = ch - CH, N - CH = n - CH or CH - CH = n, ch Z represents NH y is - C ~ 3 - 9 ~ alkyl -,C ~ 1 - 5 ~ alkyl nr\u00ac 13\u00ac - C ~ 1 - 5 ~ alkyl, - C ~ 1 - 6 ~ alkyl - NH - co - or - co NH - C ~ 1 - 6 ~ alkyl x\u00ac 1\u00ac represents 0 or nr\u00ac 11\u00ac x\u00ac 2\u00ac represents C ~ 1 - 2 alkyl -, - 0 - C ~ 1 - 2 ~ alkyl.- O - or - 0 - CH ~ 2 ~ - r\u00ac 1\u00ac represents hydrogen or halo r\u00ac 2\u00ac represents hydrogen, cyano, halo, hidroxicarbonil, C ~ 1 - 4 ~ alquiloxicarbonil.Het\u00ac 16\u00ac - carbonyl - or ar\u00ac 5\u00ac r\u00ac 3\u00ac represents hydrogen r\u00ac 4\u00ac represents hydroxy, C ~ 1 - 4 ~ alquil\u00f3xi.Ar\u00ac 4\u00ac - C ~ 1 - 4 ~ alquil\u00f3xi or r\u00ac 4\u00ac is C ~ 1 - 4 ~ alquil\u00f3xi replaced by one or when possible two or more substituents selected from C ~ 1 - 4 ~ alquil\u00f3xi - or het\u00ac 2\u00ac r\u00ac 11\u00ac represents HydroGenius r\u00ac 12\u00ac represents hydrogen, C ~ 1 - 4 ~ alkyl - or C ~ 1 - 4 ~ alkyl \u00f3xi - carbonyl - r\u00ac 13\u00ac represents het\u00ac 14\u00ac - C ~ 1 - 4 ~ alkyl.In particular morfolinil - C ~ 1 - 4 ~ alkyl het\u00ac 2\u00ac represents a heterociclo selected morfolinila or piperidinila optionally replaced by C ~ 1 - 4 ~ alkyl -,Preferably methyl het\u00ac 14\u00ac represents morfolinila het\u00ac 16\u00ac represents a heterociclo selected morfolinila or pirrolidinila ar\u00ac 4\u00ac represents fenila ar\u00ac 5\u00ac represents fenila opcionalmBeing replaced by cyan."DERIVADOS DE PIRIDO- E PIRIMIDOPIRIMIDINA COMO AGENTES ANTIPROLIFERATIVOS". A presente invenção refere-se aos compostos da
