The present disclosure provides binding polypeptides (e.g., antibodies and immunoadhesins) comprising a modified Fc domain. The present disclosure also provides nucleic acids encoding the binding polypeptides, recombinant expression vectors, and host cells for making such binding polypeptides. Methods of using the binding polypeptides disclosed herein to treat disease are also provided.本揭示文本提供包含經修飾的Fc結構域的結合多肽(例如，抗體和免疫黏附素)。本揭示文本還提供編碼該結合多肽的核酸、重組表現載體和用於製備這類結合多肽的宿主細胞。還提供了使用本文揭示的結合多肽治療疾病的方法。
